Data were analyzed by 1‐way repeated measures ANOVA and reported as mean±SEM. Untreated MSEW mice fed a HF show a lower increase in SBP, whereas enalapril treatment abolishes differences in response between control and MSEW mice. A, Delta systolic blood pressure changes (delta SBP, mm Hg) in untreated and ( B) enalapril‐treated female control (white bars) and maternal separation and early weaning (MSEW) (black bars) mice fed a LF and HF in response angiotensin II (1, 10 and 50 ng/kg SC). Effect of acute angiotensin II bolus on systolic blood pressure.
Angiotensin‐converting enzyme (ACE) western blot in gonadal white adipose tissue (gWAT) shows no differences between groups.įigure S4. Angiotensinogen content is similar in control and MSEW regardless of the diet. Liver ( A) and kidney ( B) angiotensinogen content (ng/mL) in female control (white bars) and maternal separation and early weaning (MSEW) (black bars) mice fed a low‐fat diet (LF) and high‐fat diet (HF).
Data were analyzed by 2‐way ANOVA followed by Bonferroni post hoc test and reported as mean±SEM. Effect of maternal separation and early weaning (MSEW) in angiotensin II concentration (angiotensin II, ng angiotensin II/mg protein) in renal cortex of female control and MSEW mice fed a low‐fat diet (LF) and high‐fat diet (HF).
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